NovelMed Advances NM5072 for Multiple Ocular Disorders
Key Highlights
- Multi-indication precedent: Biogen’s approximately $5.6 billion acquisition of Apellis added EMPAVELI for PNH and SYFOVRE for GA, both of which contain pegcetacoplan.
- Primate proof of concept: A single intravitreal dose of NM5072 reduced CNV, hemorrhage, and retinal fibrosis in a rhesus monkey model.
- Phase I clinical experience: NM5072 completed a Phase I study in 48 healthy volunteers and received FDA Orphan Drug Designation for PNH.
- Potential extended durability: Rabbit PK/PD data estimated an ocular half-life of seven days. Translational modeling projects approximately 21 days in humans, with therapeutic levels maintained for up to 140 days.
CLEVELAND, Aug. 11, 2026 (GLOBE NEWSWIRE) -- NovelMed Therapeutics, Inc., a clinical-stage biotechnology company, announced that it is advancing NM5072 as an ocular development candidate for multiple complement-associated retinal diseases. The program is supported by efficacy findings in rhesus monkey and rabbit models, as well as Phase I clinical safety data.
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